Abstract
A series of dimeric derivatives (+)- 1, and (+)- 2, and (+)- 3a–d of l-Dopa diacetyl esters was synthesized and evaluated as potential l-Dopa prodrugs with improved physicochemical properties. All the new compounds showed chemical stability in aqueous buffer solutions (pH 1.3 and 7.4). A relatively slow release of l-Dopa in human plasma was observed.
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