Abstract
Aim . To demonstrate basic mechanisms of dimephosphon operation on skin microhaemodynamics. Materials and methods. The study of dimephosphon effect on blood microcirculation of skin in outbred male rats included registration of perfusion index, mean square deviation, variation coefficient; determination of the amplitude of blood flow oscillations in different frequency range (by laser doppler flowmetry method). Results. Dimephosphon stimulates oscillatory and non-oscillatory skin microhaemodynamic indiсes indicating the increase of peripheral tissues perfusion and blood flow modulation in microvessels due to endothelium functional activity increase, peripheral resistance decrease, increase of blood flow to the nutritive microvessel channel and venous outflow improvement. Conclusion. Vasoactive properties of dimephosphon are manifested in its ability to affect vascular and extravascular regulatory processes of blood microcirculation of skin. Microvessel endothelium and its metabolic activity associated with NO release are the most sensitive to dimephosphon effect. The ability to increase endothelium NO production is the basic mechanism of dimephosphon vasodilatory action.
Highlights
Dimephosphon stimulates oscillatory and non-oscillatory skin microhaemodynamic indiсes indicating the increase of peripheral tissues perfusion and blood flow modulation in microvessels due to endothelium functional activity increase, peripheral resistance decrease, increase of blood flow to the nutritive microvessel channel and venous outflow improvement
Vasoactive properties of dimephosphon are manifested in its ability to affect vascular and extravascular regulatory processes of blood microcirculation of skin
Microvessel endothelium and its metabolic activity associated with NO release are the most sensitive to dimephosphon effect
Summary
Выявление основных механизмов действия димефосфона на кожную микрогемодинамику. Вазоактивные свойства димефосфона проявляются в его способности влиять на сосудистые и внесосудистые регуляторные процессы микроциркуляции крови в коже. Основным механизмом вазотропного действия димефосфона является его способность усиливать продукцию NO эндотелием, что влечет за собой вазодилатирующее действие. For citation: Chuyan E.N., Ravayeva M.Y., Nefedov D.A., Zelenskaya A.V. Galenko-Yaroshevsky P.A. Dimephosphon effects on skin microhaemodynamics. DIMEPHOSPHON EFFECTS ON SKIN MICROHAEMODYNAMICS 1Crimean Federal University Named After V.I. Vernadsky, Acad. Vernadsky Av., 4, Simperopol, Republic of the Crimea, Russia, 295007 2Krasnodar Branch of FSBI “ISTC “Eye Microsurgery” named after acad. Care of Russia, Krasnyh Partisan St., 6, Krasnodar, Russia, 350000. 3Federal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Healthcare of the Russian Federation, Sedin St., 4, Krsnodar, Russia, 350063
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