Abstract
Macromolecules organize themselves into discrete membrane-less compartments through a process called liquid-liquid phase separation (LLPS). Mounting evidence has suggested that nucleosomes as well as DNA itself undergo LLPS or general condensation due to genomic repression. Current in vitro condensation studies provide valuable insight into the physical properties of condensates but lack the resolution that would allow for complex kinetic studies of multicomponent condensation. Using a supported lipid bilayer platform (SLB) in tandem with objective based total internal reflection microscopy we observe the 2-dimensional lateral movement of macromolecules at a single molecule level.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
