Abstract
The effects of the calcium channel blockers, diltiazem and verapamil on the pharmacokinetics of phenytoin were investigated in rats. Animals were given phenytoin alone or phenytoin together with either diltiazem or verapamil and the plasma samples were collected at different time intervals. The concentration of phenytoin was measured using a high performance liquid chromatographic method (HPLC). Diltiazem and verapamil significantly ( p < 0.05) increased the area under the curve (AUC), the maximum plasma concentration ( C max) and elimination half+life ( t 1:2) of phenytoin. These results suggest that a potentially harmful drug-drug interaction may occur if phenytoin is administered concurrently with either diltiazem or verapamil.
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