Abstract
Nicardipine, one of the dihydropyridine derivatives, in a nanomolar concentration range suppressed the high K +-induced neurotransmitter from cultured neuronal cells (chick embryonic neural retina cells and clonal rat pheochromocytoma cells). The high K +-induced Ca 2+ uptake into pheochromocytoma cell was also blocked by nicardipine in the same concentration range. [ 3H]Nitrendipine, another dihydropyridine derivative, bound specifically to pheochromocytoma cell homogenate in a saturable manner. We concluded that dihydropyridines block and bind to the high K +-sensitive Ca 2+ channels in neuronal cells.
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