Abstract
Triptersinoids A-E (1–5), five undescribed highly oxygenated dihydro-β-agarofuran type sesquiterpenoid polyesters, along with three known analogues were isolated from the aqueous EtOH extracts of the dried leaves of Tripterygium wilfordii. Spectroscopic techniques were used for the elucidation of their chemical structures, and the absolute configurations determined by means of electron circular dichroism (ECD) studies, including octant rule of saturated cyclohexanone and comparison between the experimental and calculated ECD data. These compounds were evaluated for the anti-inflammatory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages, and 1α,2α,8β,15-tetraacetoxy-9α-benzoyloxyl-15-nicotinoyloxy-β-dihydroagarofuran (7) and angulateoid B (8) showed potential inhibitory effects with IC50 values of 17.30 ± 1.07 μM and 20.79 ± 1.55 μM.
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