DIGITAL BIOMARKER 2D:4D AS A PREDICTOR OF CANCER: A SYSTEMATIC REVIEW

Célia Márcia Fernandes Maia,Cláudia De Alvarenga Diniz Fonseca,Renata Angélica Ferreira De Oliveira,Daniella Reis Barbosa Martelli,Verônica Oliveira Dias,Adriana Amaral Carvalho,Hercílio Martelli Júnior

doi:10.1016/j.oooo.2023.03.084

Célia Márcia Fernandes Maia, Cláudia De Alvarenga Diniz Fonseca + Show 5 more

https://doi.org/10.1016/j.oooo.2023.03.084

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Objective This study aimed to analyze and discuss the association between 2D:4D and cancer through a systematic review of the literature. Study Design This review was performed according to the criteria recommended for the systematic review of the PRISMA Statement. Twenty-five articles were selected for the systematic review, involving eleven types of cancer with 4,569 cases and 19,416 controls. Results Variations in the results of the association between 2D:4D and cancer were observed between studies, whether in those that evaluated the same or different types of cancer. The variant genes HOX, AR, and LIN28b linked to carcinogenesis and correlated with the 2D:4D ratio, a putative marker for the action of these genes, may contribute to the investigation of etiologic factors in the screening of patients with susceptibility to the development of squamous cell carcinoma. Conclusion Findings from studies involving 2D:4D as a proxy for fetal hormone exposure should be interpreted with caution. Other studies with a more homogeneous methodology to better investigate the findings should be carried out. Funding Minas Gerais State Research Foundation - FAPEMIG, Brazil; National Council for Scientific and Technological Development - CNPq, Brazil; Coordination of Improvement of Higher Education Personnel (CAPES), Brazil This study aimed to analyze and discuss the association between 2D:4D and cancer through a systematic review of the literature. This review was performed according to the criteria recommended for the systematic review of the PRISMA Statement. Twenty-five articles were selected for the systematic review, involving eleven types of cancer with 4,569 cases and 19,416 controls. Variations in the results of the association between 2D:4D and cancer were observed between studies, whether in those that evaluated the same or different types of cancer. The variant genes HOX, AR, and LIN28b linked to carcinogenesis and correlated with the 2D:4D ratio, a putative marker for the action of these genes, may contribute to the investigation of etiologic factors in the screening of patients with susceptibility to the development of squamous cell carcinoma. Findings from studies involving 2D:4D as a proxy for fetal hormone exposure should be interpreted with caution. Other studies with a more homogeneous methodology to better investigate the findings should be carried out.

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