Abstract
A new digital imaging system for beta and gamma autoradiography has been realized. The technological advancement of this imaging system is represented by the second-generation Medipix2 chip (a single photon/particle counting chip), developed at CERN in the framework of the Medipix2 European collaboration, as a successor of the Medipix1 chip. Medipix2 is realized in 0.25 /spl mu/m CMOS technology; it has a sensitive area of 14/spl times/14 mm/sup 2/ and a pixel pitch of 55 /spl mu/m, it has been bump-bonded to a 300 /spl mu/m thick silicon pixel detector. A dedicated electronic interface and a complete image acquisition and processing software allow to operate this hybrid pixel detector for digital autoradiography with acquisition time as long as several days. In a preliminary test of this imaging system for digital autoradiography we obtained a detection threshold of 1600 electrons (equivalent to about 6 keV in Si), a noise of 10/sup -3/ cps/mm/sup 2/, a minimum detectable activity of 0.32 Bq in 14 h for /sup 3/H and 0.012 Bq in 10 h for /sup 14/C. A preliminary spatial resolution test for /sup 14/C gives a FWHM resolution of 30 /spl mu/m. Real time images of /sup 3/H, /sup 14/C, /sup 125/I autoradiographic microscales are also presented.
Published Version
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