Abstract
Ras is a small GTP binding protein. Specific point mutations can lead to a constant activation of Ras molecule. Over expression of mutated Ras molecule induced morphological transformation of NIH3T3 cells in culture and these transformed cells had the ability to induce tumors in nude mice. The activation mutations in Ras molecule play a significant role in tumor formation and development. The critical role of Ras signaling in human cancer is proved by the fact that it is one of the most highly mutated genes in human cancer, with approximately 90% incidence of activating mutation in pancreatic cancer, 50% in colon and 30% in many other types.
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