Abstract
Diffusion-weighted Whole-body MRI at 3 Tesla for the Detection and Discrimination of Pulmonary Tumors
Highlights
Standard imaging techniques provide a high sensitivity for detection of pulmonary lesions specificity is limited[1]
Diagnostic accuracy can be improved by using functional techniques such as Dynamic Contrast Enhanced (DCE) CT, 18F-labeled 2-Fluoro-2-Deoxy-D-Glucose (FDG) Positron Emission Tomography (PET), 99mTc-depreotide Single Photon Emission Computed Tomography (SPECT), DCE MRI, and Diffusion-Weighted Imaging (DWI)[2]
Patient Population The study was approved by the local institutional review board, and written informed consent was obtained from all patients. 19 consecutive patients (12 male, 7 female; mean age: 65 years; age range: 27 - 79 years) with 25 pulmonary lesions suspected of being primary lung cancers at chest CT were included
Summary
Standard imaging techniques provide a high sensitivity for detection of pulmonary lesions specificity is limited[1]. Diagnostic accuracy can be improved by using functional techniques such as Dynamic Contrast Enhanced (DCE) CT, 18F-labeled 2-Fluoro-2-Deoxy-D-Glucose (FDG) Positron Emission Tomography (PET), 99mTc-depreotide Single Photon Emission Computed Tomography (SPECT), DCE MRI, and Diffusion-Weighted Imaging (DWI)[2]. In comparison to DCE CT, DCE MRI, FDG PET and SPECT, with DWI lower sensitivity but higher specificity for differentiation of malignant from benign lung lesions was found[2,5]. Recent studies even found higher sensitivity and equal specificity for DWI compared to FDG PET[6,7]. As an adjunct to DCE MRI, DWI can improve the diagnostic accuracy of DCE MRI[9]
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