Abstract
To assess mediastinal lymphadenopathy in children with diffusion-weighted MR imaging. Retrospective analysis of 29 consecutive children (18 boys and 11 girls aged 2-15years) with mediastinal lymphadenopathy. They underwent single-shot echo planar diffusion-weighted MR imaging of the mediastinum with b factors of 0, 300, and 600s/mm(2). The ADC value of the mediastinal lymph nodes was calculated and correlated with biopsy results; statistical analysis was also performed. The mean ADC value for malignant mediastinal lymphadenopathy (n=20) (0.99±0.18×10(-3)mm(2)/s) was significantly lower (P=0.001) than that for benign lymphadenopathy (n=9) (1.35±0.26×10(-3)mm(2)/s). There was significant difference between ADC values for non-Hodgkin lymphoma and metastatic nodes (P=0.04). For differentiating malignant from benign mediastinal lymphadenopathy, the best result was obtained when an ADC value of 1.22×10(-3)mm(2)/s was used as a threshold value; area under the curve was 0.861, accuracy 93.1%, sensitivity 100%, specificity of 77.8%, positive predictive value 90.9%, and negative predictive value of 100%. Diffusion-weighted MR imaging is a promising non-invasive imaging modality that can be used for differentiation of malignant from benign mediastinal lymphadenopathy in children.
Published Version
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