Diffusion weighted MRI and tractography for evaluating peripheral nerve degeneration and regeneration.

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Accurately documenting and quantifying peripheral nerve axonal degeneration and regeneration is critically important for clinical research in peripheral nerve disorders such as nerve trauma, peripheral neuropathy and amyotrophic lateral sclerosis (ALS). Current strategies include clinical assessments and neurophysiological studies (including nerve conduction studies and electromyography (EMG)). However, the information provided by these strategies is limited in a number of ways.