Abstract
Gadolinium (Gd3+) is a commonly used in MRI. The role of Gd3+ as contrast agent greatly helps to improve the quality of an image and Gadolinium entrance in a body through a diffusion process after administration. Diffusion process takes place from outside pre-synapse to inside pre-synapse through Ca2+ channels. This process causes a delay of Ca2+ in passing Ca2+ channels to pre-synapse. This study aims to determine equilibrium concentration of Ca2+ and Gd3+ so that Ca2+ can pass Ca2+ channels. To address the effect of Gd3+ concentration around Ca2+ channels, we developed a Monte Carlo simulation on Ca diffusion and interaction with Gd. We find Gd3+ concentration in a certain threshold can be potential as a blocker Ca2+ diffuse entrance into pre-synapse. In another hand, an amount of Ca2+ channels and pre-synapse terminal to continuing diffusion of vesicles to clef was important. And the trapping Gd3+ in pre-synapse effects in diffusion delays also. These simulations identify characteristics of the interaction between Ca2+ and Gd3+ in Ca channels which entrance into pre-synapse through diffusion process depend on concentration with each other.
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