Abstract
Our purpose was to assess the influence of liver steatosis on diffusion by triexponential analysis. Thirty-three patients underwent diffusion-weighted magnetic resonance imaging with multiple b values for perfusion-related diffusion, fast free diffusion, and slow restricted diffusion coefficients (D p, D f, D s) and fractions (F p, F f, F s). They also underwent dual-echo gradient-echo imaging for measurement of the hepatic fat fraction (HFF). Of these, 13 patients were included in the control group and 20 in the fatty liver group with HFF >5%. The parameters of the two groups were compared by use of the Mann-Whitney U test. The relationships between diffusion coefficients and HFFs were assessed by use of the Pearson correlation. D p and D f were reduced significantly in the steatotic liver group compared with those in the control group (D p=27.72±6.61×10(-3) vs. 33.33±6.47×10(-3)mm(2)/s, P=0.0072; D f=1.70±0.53×10(-3) vs. 2.06±0.40×10(-3)mm(2)/s, P=0.0224). There were no significant differences in the other parameters between the two groups. Furthermore, D p and D f were correlated with HFF (P<0.0001, r=-0.64 and P=0.0008, r=-0.56, respectively). Decreased liver perfusion in steatosis caused the reduction in D p, and extracellular fat accumulation and intracellular fat droplets in steatosis led to the reduction in D f. Thus, the influence of hepatic steatosis should be taken into consideration when triexponential function analysis is used for assessment of diffuse liver disease.
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