Diffuse speckle contrast analysis with novel fiber-lens detection

Abstract

To date, various blood flow measurement systems have been presented. Recently we demonstrated multi-channel diffuse speckle contrast analysis (DSCA) to monitor in-vivo relative blood flow in deep tissues noninvasively. It has a limitation in a long-term use due to camera contamination. Here, we present a novel fiber-lens combined DSCA which can solve it. Also it has been applied to cerebral blood flow monitoring of rats during middle cerebral artery occlusion surgery. As a result, the system showed relative changes of the flow during the arterial perfusion periods. It secures novel applications of the DSCA in in-vivo blood flow measurement.