Abstract

Methods We performed CMR in 24 patients with idiopathic nonischemic cardiomyopathy (16 men, mean age 58±11 years) and also in 12 healthy volunteers as control subjects. T1 mapping was performed with post-contrast Look-Locker gradient echo. Baseline echocardiography as well as hemodynamic and metabolic data were collected at the time of CMR. Patients were followed over a median time of 8 months for LVRR which was defined as a left ventricular ejection fraction (LVEF) increase of ≥10 U and a decrease in indexed left ventricular end-diastolic diameter (LVEDD) of ≥10% or indexed LVEDD of < 33 mm/m at 24 months. A multivariable logistic regression analysis was performed to identify associations with LVRR.

Highlights

  • Diffuse myocardial fibrosis may be a fundamental features of adverse myocardial remodeling in idiopathic non-ischemiccardiomyopathy

  • As T1-weighted cardiac magnetic resonance (CMR) imaging provides an alternative method of diffuse fibrosis quantification, we sought to assess the association of myocardial T1 value to left ventricular reverse remodeling (LVRR)

  • Patients were followed over a median time of 8 months for LVRR which was defined as a left ventricular ejection fraction (LVEF) increase of ≥10 U and a decrease in indexed left ventricular end-diastolic diameter (LVEDD) of ≥10% or indexed LVEDD of < 33 mm/m2 at 24 months

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Summary

Open Access

But not focal fibrosis identified with delayed enhancement, is an independent predictor of LV reversed remodeling in patients with idiopathic non-ischemic cardiomyopathy. From 16th Annual SCMR Scientific Sessions San Francisco, CA, USA. From 16th Annual SCMR Scientific Sessions San Francisco, CA, USA. 31 January - 3 February 2013

Background
Methods
Results
Presence of myocardial scar

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