Relationship between red blood cell distribution width and left ventricular reverse remodeling in dilated cardiomyopathy

Abstract

Objective To evaluate the prognostic value of baseline red cell distribution width (RDW) for left ventricular reverse remodeling (LVRR) in patients with dilated cardiomyopathy (DCM) . Methods Patients with newly diagnosed DCM who admitted to Fujian Medical University Union Hospital from June 1, 2007 to June 30, 2012 were reviewed and those had follow-up RDW and echocardiogram after 9 months were enrolled. Multivariate logistic regression analysis was used to evaluate the prognostic value of baseline parameters for LVRR, defined as an absolute increase in left ventricular ejection fraction (LVEF) ≥10% or a follow-up LVEF≥50% accompanied by a decrease in left ventricular end-diastolic diameter index (LVEDDI) ≥10% or an LVEDDI ≤33 mm/m2 as assessed by echocardiography during follow-up. Results A total of 145 patients were enrolled. After a mean follow-up duration of (12.4±2.4) months, LVRR was found in 53 patients (36.55%) . Compared to those without LVRR, patients with LVRR had a significantly lower LVEDDI, left ventricular end-systolic diameter index (LVESDI) , RDW (all P 120 ms (P<0.05) at baseline. Multivariate logistic regression analysis showed that both baseline RDW[odds ratio (OR) 1.45, 95% confidence interval (CI) 1.12-1.89, P=0.005] and LVEDDI (OR 1.79, 95%CI 1.18-2.72, P=0.006) were independent predictors of LVRR in patients with DCM. Conclusion Both lower RDW and LVEDDI at baseline were independent predictors LVRR in DCM. Key words: Cardiomyopathy, dilated; Left ventricular reverse remodeling; Red cell distribution width