Difficulties in diagnosing progressive supranuclear palsy

Abstract

Progressive supranuclear palsy is a sporadic neurodegenerative disease manifested by oculomotor disorders, akinetic- rigid syndrome, early development of postural instability, gradual development of frontal dementia, and pseudobulbar syndrome. Diagnosis of PNP is determined by the specifi c topical distribution of the degenerative lesion in the brain. This article describes a clinical case of a 67-year-old patient with PNP, a feature of which is the complexity of diff erential diagnosis, given the presence of a variety of comorbidities.