Abstract
The antineoplastic agent cytarabine and the natural nucleoside cytidine are biologically interesting substances with the same chemical composition (the cytarabine arabinose moiety is epimeric with cytidine ribose). Because both compounds appear together in biochemical reactions when cytarabine is used in cancer chemotherapy, it is important to find a sensitive, direct and rapid analytical method to determine both cytarabine alone and the cytarabine + cytidine mixtures. In this study differential pulse polarography was employed for the quantitative analysis of cytarabine in buffered aqueous media. The dependence of the differential pulse peak on several parameters was studied, and the optimum conditions for analytical determination were found. The cytarabine peak could only be observed at concentrations above 3 μM, but the detection limit for cytarabine was estimated at 0.4 μM because of the catalytic effect of cytarabine reduction products on hydrogen ion reduction. Different mixtures of cytarabine + cytidine were also investigated, and the detection limits were estimated at 1 μM for cytidine and 6 μM for cytarabine.
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