Abstract
The antineoplastic agent 5-azacytidine, one of the antimetabolites, has been studied systematically using polarography, cyclic voltammetry and coulometry in the buffered aqueous medium pH 6.4 at 5°C, conditions for maximum stability of the 1,3,5-triazine ring. The reduction mechanism proposed is an overall two-electron process, where the reducible group is the N(5)=C(6) double bond. Differential pulse polarography has been employed for its quantitative analysis at the optimum found conditions, and a detection limit of 0.4 μM was estimated. As both compounds appear together in biochemical reactions when 5-azacytidine is used in cancer chemotherapy, different mixtures of 5-azacytidine + cytidine have also been investigated at micromolar level and a mean error of about 2% was obtained.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
