Differential pulse adsorption voltammetry for determination of procaine hydrochloride at a pumice modified carbon paste electrode in pharmaceutical preparations and urine

Abstract

Procaine hydrochloride was determined by the differential pulse voltammetry (DPV) using a 6% (m/m) pumice modified carbon paste electrode in 1.25×10 −3 mol l −1 KH 2PO 4 and Na 2HPO 4 buffer solution (pH 6.88, 25 °C). The anodic peak potential used was +0.980 V (vs. SCE). A good linear relationship was realized between the anodic peak current and procaine concentration in the range of 9.0×10 −7–2.6×10 −5 mol l −1 with the detection limit of 5.0×10 −8 mol l −1. The recovery was 95.2–104.8% with the relative standard deviation of 3.2% ( n=10). The pharmaceutical preparations, procaine hydrochloride injection and the urine samples were determined with the desirable results.