Abstract
The evidence that both TRH and somatostatin (SRIF) control TSH secretion prompted this study of the hypothesis that slow wave sleep (SWS)-induced GH secretion may be related to a decrease in hypothalamic SRIF release. Ten adult men spent 1 accommodation night, followed by 2 experimental nights, in the sleep laboratory, during which electroencephalogram monitoring and blood sampling by iv catheter were performed. Subjects received TRH (50µg, iv) in 0.5 ml saline or saline alone during SWS and rapid eye movement sleep (REM) on 1 night and a reversed injection protocol on the other night. Each subject received only one TRH injection per night, during either SWS or REM. Blood was sampled every 30 min during sleep (lights off from 2300–0700 h), except immediately after each injection, when samples were taken at 0, 5, 10, 15, 30, 45, 60, 90, and 120 min. Serum TSH, GH, PRL, and cortisol levels were determined by RIA. Characteristic sleep patterns of GH and cortisol secretion were observed in these subjects, wit...
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call