Differential integrin expression regulates cell sensing of the matrix nanoscale geometry.

Abstract

The novel nanofiber patterns developed in this study, via ENL, mimic the geometry and continuity of natural matrices found in the stroma of tissues, whilst preserving a quasi-2D character (to facilitate imaging and for comparison with other 2D systems such as micropatterned monolayers and circular nanopatches generated by colloidal lithography). These results demonstrate that the nanoscale geometry of the ECM plays an important role in regulating cell adhesion and that this is modulated by integrin expression. This is an important finding as it implies that the knowledge of the biochemical context underlying the integrin-mediated adhesive machinery of specific cell types should allow better design of biomaterials and biointerfaces. Indeed, changes in integrin expression are often associated with the control of cell proliferation and differentiation.