Abstract
While aluminum adjuvant-based vaccines are commonly administered to neonates, their immune effects specific to early life are not well understood. The immature infant immune system is Th2-biased and dependent on environmental cues to mature towards Th1/Th2 balance. Thus, the induction of strong Th2 immunity with alum vaccines in early life may perturb this balance, leading to predisposition towards development of Th2 immunity to subsequent allergen exposure.
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