Abstract
Objectives: The human fibulin (Fbln) family consists of seven extracellular glycoproteins involved in elastogenesis as well as cell adhesion, migration and proliferation. Distinct fibulins, in both tumor and stromal cells, are differentially regulated in malignancy. In general, Fbln3 and -5 bind to other matrix components to suppress angiogenesis and epithelial cell motility. In the female reproductive tract, Fbln5 serves not only in the assembly of elastic fibers but also inhibits superoxide dismutase and MMP9.
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