Abstract
The effect of unilateral subthalamic nucleus ablation on rotation in response to dopamine D 1 and D 2 agonists was examined in rats with a unilateral 6-OHDA lesion of the nigrostriatal pathway. Four to five weeks following subthalamic nucleus lesion, D 2 agonist-induced rotation was reduced in subthalamic nucleus-lesioned rats relative to sham controls, although no such reduction in D 1 agonist-induced circling occured. However, 1–2 weeks following subthalamic nucleus lesion marked reductions occurred in both D 1 and D 2 agonist-induced rotation in subthalamic nucleus lesioned rats compared to sham controls. These results suggest that the subthalamic nucleus contributes primarily to the expression of D 2-mediated motor behaviors, although ablation of the subthalamic nucleus may induce certain time-dependent compensatory mechanisms in other basal ganglia structures which affect D 1-mediated actions.
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