Abstract
Summary No cytotoxic doses of methyl-isobutyl-amino-adenosine (MIBUNA) were shown to inhibit the replication of murine leukaemia viruses (MuLv) when the treatment was initiated after viral infection. In contrast, enhancement of focus formation was observed when cells were treated with low doses of MIBUNA after infection with a defective murine sarcoma virus (MSV) in the absence of exogenous helper MuLv. The stimulation occurred independently of the nature of the cells used. MIBUNA had no effect on the induction of endogenous virus in K BALB/c cells. Thus, transformation can distinguished be from helper replication using MIBUNA.
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