Abstract
Abstract To study the application value and significance of 34E12, cytokeratin 19 （CK l 9）and thyroper oxidase（TP0） in the differential diagnosis between papillary thyroid carcinomas and benign thyroid papillary hyperplasia. Methods The expression of 34 β E 12, CK19 and TP0 protein in 38 cases of papillary thyroid carcinomas, 15 cases of thyroid nodular goiter with papillary hyperplasia and 15 cases of adenomas with papillary hyperplasia were detected by immunohistochemistry method. Results The positive rats of 34β E 12, CK19 and TP0 in papillary thyroid carcinomas and hyperplasia diseaseof thyroid were 89.5% and 3.3% （P〈 0.01）; 84.2% and 16.7% （P〈 0.01）; 10.5% and 96.7% （P〈 0.01）. Conclusion 34β El2, CK19 and TP0 expressions are useful in differential diagnosis for papillary thyroid carcinoma and benign papillary thyroid hyperplasia. Key words: Papillary thyroid carcinoma; High molecular weight cytokeratin（34 ~ E 12 ）; Cytokeratin19（CK19）; Thyroperoxidase（TP0）; Immunohistochemistry
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