Differential diagnosis value of Copenhagen index, risk of ovarian malignancy algorithm and risk of malignancy index for benign and malignant ovarian epithelial tumors

Abstract

Objective To investigate the differential diagnosis value of Copenhagen index (CPH-I), risk of ovarian malignancy algorithm (ROMA) and risk of malignancy index (RMI) for benign and malignant ovarian epithelial tumors. Methods The clinical data of 515 patients with ovarian epithelial tumors in the Second Affiliated Hospital of Zhengzhou University from January 2014 to January 2018 were retrospectively analyzed. The patients were divided into benign group and malignant group according to postoperative pathology. The predicted value of CPH-I, ROMA and RMI was calculated. The receiver-operating characteristic (ROC) curve was drawn with surgical pathology as the gold standard, while the area under the curve (AUC) and the sensitivity and specificity of different indexes under the corresponding cut-off values were calculated. The diagnostic effects of CPH-I, ROMA and RMI on benign and malignant ovarian epithelial tumors were compared. Results ①The predictive value of CPH-I, ROMA and RMI in the malignant group was higher than that in the benign group (P<0.01). ②The area under curve of CPH-I, RMOA and RMI was 0.937, 0.936 and 0.906, respectively. The results of diagnostic efficacy comparison showed that ROMA was better than RMI (P=0.0473); CPH-I was better than RMI (P=0.0293). There was no significant difference in diagnostic efficacy between CPH-I and ROMA (P=0.8494). Conclusions CPH-I, ROMA and RMI have high diagnostic efficacy on benign and malignant ovarian epithelial tumors. CPH-I and ROMA have comparable diagnostic efficacy, which are superior to RMI. Key words: Ovarian epithelial tumors; Copenhagen index; Risk of ovarian malignancy algorithm; Risk of malignancy index