Abstract
Investigators at Pitie-Salpetriere and Robert Debre Hospitals, and other centers in France, evaluated consecutive patients referred for suspected Kleine-Levin (KLS) syndrome, detailed differential diagnoses, and examined characteristics of patients with prolonged (>30 days) episodes.
Highlights
The diagnosis is by exclusion, ruling out narcolepsy, temporal lobe epilepsy, Kluver-Bucy syndrome, metabolic disorders, bipolar and other mental disorders, and MS
A PubMed search uncovers several reports of KLS following viral encephalitis [4] and occasional cases that responded to antiepileptic medications
The author(s) have declared that no competing interests exist
Summary
Suspected causes include hypothalamic dysfunction or autoimmune disorder, and precipitants are infection, alcohol or head trauma.
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