Differential binding of piperine & curcumin with modified cellulose, alginate and pectin supports: In-vitro &in-silico studies

Abstract

Use of natural polymer in the development of Drug Delivery Systems (DDS) has greatly increased in recent past because of their biocompatible, non-allergic and biodegradable nature. Natural polymers are usually hydrophilic supports, so in order to be a carrier of a hydrophobic drug their nature needs to be changed. Each developed system behaves differently towards different drugs in terms of loading and sustained release of the drug as well. In the present work we report differential binding of piperine & curcumin with cetyltrimethylammonium bromide (CTAB) modified cellulose, alginate and pectin. Difference in interaction between the piperine and curcumin with supports has been visualized using in-vitro as well as in-silico studies. Initial results obtained after in-silico studies have been validated via time dependent anti-trypsin, serum protein binding, anti-cathepsin, anti-oxidant, and anti-α-amylase activities. FT-IR, SEM, fluorescence and Particle size have been used to characterize the piperine loaded on CTAB-modified polymeric supports.