Abstract
Differential Antimicrobial Effectiveness of Camel Lactoferrin-Oleic Acid and Bovine Lactoferrin-Oleic Acid Complexes against Several Pathogens
Highlights
Lactoferrin is an 80 kDa iron-binding glycoprotein, which is found in numerous secretory fluids, for example milk [1]
For the first time, their differential antimicrobial activity against several pathogens was evaluated by agar disc diffusion method and broth micro dilution assay, estimating Lf binding to bacterial outer membrane proteins by ELISA
Antimicrobial Agents cLF and Bovine Lactoferrin (bLf) were purified from camel and bovine milk after processing at our lab according to the protocol described by Redwan & Tabll (2007) [13]
Summary
Lactoferrin is an 80 kDa iron-binding glycoprotein, which is found in numerous secretory fluids, for example milk [1]. Lf displays antimicrobial activity against a variety of pathogenic microorganisms besides modulating the immune system. Lactoferrin has a variety of biological functions, many of which not related to its iron-binding capability [4]. Long-chain unsaturated fatty acids such as OA and linoleic acid are bactericidal to various pathogens including MRSA and Helicobacter pylori [6,7]. They have in vitro killing activity against C. albicans [8]. Both LF and α-Lactalbumin (α-LA) have similar iron-binding region structure [9]. For the first time, their differential antimicrobial activity against several pathogens was evaluated by agar disc diffusion method and broth micro dilution assay, estimating Lf binding to bacterial outer membrane proteins by ELISA
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