Different Treatment Interventions Affect Plasma NT-ProBNP Levels and Early Exercise Tolerance in Patients with Acute ST-Segment Elevation Myocardial Infarction

Abstract

Objective: The aim of this study was to investigate the effect of different treatment interventions on plasma N–terminal fragment of the prohormone brain natriuretic peptide (NT–proBNP) levels and early exercise tolerance in patients with acute ST–segment elevation myocardial infarction. Methods: 146 consecutive patients with ST–segment elevation myocardial infarction who received emergency percutaneous coronary intervention (PCI) (n = 55), elective PCI (n = 47), or drug treatment (n = 44) were included. Plasma NT–proBNP levels and left ventricular ejection fractions (LVEFs) were measured before the treatment intervention and at 1 week and 1 month afterward. An exercise stress test was performed 1 month after the intervention, and the occurrences of major adverse cardiac events (MACE) were recorded at the 1-month follow–up. Results: Compared with the elective PCI and drug treatment groups, at 1 week and 1 month after the intervention, the emergency PCI group's plasma NT–proBNP levels were significantly lower, and the group's LVEFs were significantly higher (all P < 0.05). There was a significantly negative correlation between plasma NT–proBNP levels and LVEFs in each group (all P < 0.05). The positive exercise stress testing rates were 13.0%, 32.6%, and 38.6% in the emergency PCI, elective PCI, and drug treatment groups, respectively (P < 0.05). The occurrences of MACE in the emergency PCI, elective PCI, and drug treatment groups were 34.5%, 59.5%, and 65.9%, respectively (P < 0.05). Conclusion: Emergency PCI resulted in lower plasma NT–proBNP levels, lower MACE incidence, higher LVEFs, and better early exercise tolerance compared with elective PCI or drug treatment, indicating that lower plasma NT–proBNP levels predicted a better prognosis.