Abstract
Coughlin and colleagues [1] recently examined the association between hippocampal α-synuclein (SYN) and tau pathologies in 49 autopsy-confirmed cases of Lewy body diseases (LBD) - 30 with no/low Alzheimer disease (AD) co-pathology (LBD - AD) and 19 with moderate/high AD co-pathology (LBD + AD) aged at death 77.3 and 78.6 years, and disease duration 15.8 and 9.1 years, respectively, and 30 AD patients with a mean age of 74.4 years. 67% and 89%, respectively, were neocortical, 27% and 11%, respectively, limbic LBD stage, with only very few brainstem predominant forms [2]. LBD - AD and LBD + AD had similar severity and distribution of SYN pathology, subfield CA 2/3 being most severely affected, while CA1/subiculum and entorhinal cortex (ERC) were the most affected regions in AD. Tau pathology in both LBD - AD and LBD + AD was greatest in about two thirds, suggesting that tau burden in LBD was similar to the distribution of SYN in subfield CA 2/3, thus diverging from that in classical AD and contributing to memory dysfunction in LBD. β-Amyloid severity and distribution were similar between LBD + AD and AD.
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