Abstract
Nicotinamide crystallizes with 3-hydroxy-2-naphthoic acid and 4-aminobenzoic acid to give rise to cocrystal 1 and 2, respectively. Cocrystal 1, [C11H8O3][C6H6N2O], crystallizes in the monoclinic space group C2/c with a = 25.810(4), b = 4.8932(5), c = 23.869(4) A, β = 107.078(8)o, V = 2881.6(7) A3, Z = 8, C17H14N2O4, M r = 310.30, D c = 1.431 g/cm3. Cocrystal 2, [C7H7NO2][C6H6N2O]·H2O, crystallizes in the triclinic space group P-1 with a = 7.214(5), b = 7.326(5), c = 13.484(11) A, α = 83.23(2), β = 77.189(18), γ = 80.35(2)o, V = 682.7(9) A3, Z = 2, C13H15N3O4, M r = 277.28, D c = 1.349 g/cm3. Similar carboxylic acid···pyridine synthon R 2 2 (7) can be observed in the two cocrystals. In 1, amide of nicotinamide forms a C(4) chain from the anti H to its carbonyl oxygen. In 2, the amide forms a R 2 2 (8) homodimer which is linked into 2D layer by water molecule through different hydrogen-bonding interactions. The 3D hydrogen-bonded structure results from a synthon R 4 2 (8) from amide, water and amino group of 4-aminobenzoic acid. Nicotinamide crystallizes with 3-hydroxy-2-naphthoic acid and 4-aminobenzoic acid to give rise to cocrystal 1 and 2, respectively. Similar carboxylic acid···pyridine synthon R 2 2 (7) can be observed in the two cocrystals. In 1, amide of nicotinamide forms a C(4) chain from the anti H to its carbonyl oxygen. The syn H is accepted by hydroxyl oxygen of 3-hydroxy-2-naphthoic acid to form an infinite C 2 2 (12) chain. In 2, the amide forms a R 2 2 (8) homodimer which is linked into 2D layer by water molecule through different hydrogen-bonding interactions. The 3D hydrogen-bonded structure results from a synthon R 4 2 (8) from amide, water and amino group of 4-aminobenzoic acid.
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