Different Genotype Distribution of Human Papillomavirus between Cervical and Esophageal Cancers: A Study in Both High-Incidence Areas, Xinjiang, China.

Yi Zheng,Yage Fan,Shiyu Liu,Yan Zeng,Limin Gao,Maciej Gagat

doi:10.1155/2020/7926754

Abstract

The aim of this study is to reveal the certain human papillomavirus (HPV) genotype distribution between cervical cancer and esophageal cancer in the both high-incidence geographic regions. For this study, we collected and detected the infection of HPV in 120 paraffin-embedded esophageal tissues and 152 paraffin-embedded cervical tissues, respectively. The esophageal tissues include 40 normal epithelium (ENOR), 26 dysplasia (DYS), and 54 invasive squamous cell carcinoma (ESCC). The cervical tissues consisted of 40 normal epithelium (CNOR), 53 intraepithelial neoplasia (CIN), and 59 invasive squamous cell carcinoma (CSCC). Both esophageal and cervical tissues collected in this study came from the same area, in which both the ESCC and CSCC were in high incidence, Xinjiang province, China. HPV GenoArray test kits were served to analyze the HPV infection. The result shows that among the 59 CSCC tissues, the total infection rate of HPV was 98.3% (58/59). The positive rate of HPV-16 infection was 63.8% (37/58). It indicated that HPV-16 is the most common infection among all of the high-risk HPV. The multiple infection rate was 19.0% (11/58). Among the 54 ESCC, a total of 7 genotypes were detected. The total infection rate of HPV was 61.1% (33/54). The positive rate of HPV-16 infection was 63.6% (21/33). The multiple infection rate was 6.1% (2/33). Our result shows that high-risk-type HPV-16 was associated with both cervical cancer and esophageal cancer, which play a role in the high-incidence area in Xinjiang. We hope that our results could point out the direction for the treatment strategy of HPV-associated cancer, cervical cancer, and esophageal cancer and for the application of HPV vaccines in the future.

Highlights

Human papillomavirus (HPV) is an extremely common pathogen for human infection and can cause many benign and malignant diseases, including cervical, anal, vulvar, penile, and oropharyngeal cancers [1]
There are more than 100 subtypes of HPV, which are divided into high risk and low risk based on their propensity to cause cancer
high-risk human papillomaviruses (HR-HPVs)-associated cancers closely correlated with different anatomic sites, geographical areas, and smoking status, leading to almost 100% cervical cancer, 88% anal cancer, and less than 50% lower genital tract and oropharyngeal cancer [4]

Summary

Introduction

Human papillomavirus (HPV) is an extremely common pathogen for human infection and can cause many benign and malignant diseases, including cervical, anal, vulvar, penile, and oropharyngeal cancers [1]. There are more than 100 subtypes of HPV, which are divided into high risk and low risk based on their propensity to cause cancer. It was reported that high-risk human papillomaviruses (HR-HPVs) brought about more than 600,000 cancers in 2008, which bring huge pressure and enormous challenges for public health [2]. Infection by high-risk anogenital HPV is a necessary cause of cervical cancer (CC) [3]. HR-HPV-associated cancers closely correlated with different anatomic sites, geographical areas, and smoking status, leading to almost 100% cervical cancer, 88% anal cancer, and less than 50% lower genital tract and oropharyngeal cancer [4]

Objectives

Methods

Results