Different contributions of nonmuscle myosin IIA and IIB to the organization of stress fiber subtypes in fibroblasts.

Abstract

We demonstrated that myosin IIA and IIB are essential for the formation of transverse arcs and ventral stress fibers, respectively. Furthermore, we illustrated the roles of both isoforms in lamellar flattening and also raised the possibility that actin filaments in ventral stress fibers are in a stretched conformation.