Abstract
Urinary levels of tryptophan metabolites before and after tryptophan loading were compared between breast cancer groups with and without cancer at other sites. Metabolism was significantly elevated in the group with cancer at other sites suggesting a relationship between extent of disease and increased levels of tryptophan metabolites. Results from comparisons of male bladder cancer cases having Grades III and IV lesions with those having Grades I and II lesions were in the same direction, but were less marked than seen in the breast cancer groups. The differences in tryptophan metabolism in breast cancer patients may possibly represent an imbalance in hormone levels known to affect tryptophan metabolism.
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