Abstract
Prostacyclin (PGI 2) is a potent vasodilator and inhibitor of platelet aggregation, however, its half-life in aqueous solutions at neutral or acid pH is very short. In this study we have investigated the stability of PGI 2 in plasma from different species and have demonstrated that the half-life of the anti-aggregatory and the hypotensive activity of PGI 2 is considerably prolonged in human plasma. Interestingly the activity of PGI 2 was not maintained on incubation in rat or rabbit plasma indicating that the stabilising factor may be confined to human plasma. Whether such stabilisation prolongs the half-life of PGI 2 in the human circulation merits investigation.
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