Abstract
The analysis of chondroitin sulfates from the epiphysial growth cartilages of vertebral bodies and long bones from 5 subjects is reported. The cartilages from the vertebral bodies contain an average of 77% of chondroitin sulfate C and 23% of chondroitin sulfate A, whereas cartilages from long bones (femur and humerus) contain an average of 41% of chondroitin sulfate C and 59% of chondroitin sulfate A. These results are correlated with a chemical defect of chondroitin sulfate C in a new mucopolysaccharidosis characterized by platyspondyly (flat vertebrae).
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