Abstract
The lateral septum (LS), which is innervated by the hippocampus, is known to represent spatial information. However, the details of place representation in the LS, and whether this place information is combined with reward signaling, remains unknown. We simultaneously recorded from rat CA1 and caudodorsal lateral septum in rat during a rewarded navigation task and compared spatial firing in the two areas. While LS place cells are less numerous than in hippocampus, they are similar to the hippocampus in field size and number of fields per cell, but with field shape and center distributions that are more skewed toward reward. Spike cross-correlations between the hippocampus and LS are greatest for cells that have reward-proximate place fields, suggesting a role for the LS in relaying task-relevant hippocampal spatial information to downstream areas, such as the VTA.
Highlights
The lateral septum (LS), which is innervated by all CA fields of the hippocampus, contains place cells, and processes spatial information received from the hippocampus (Bezzi, 2005; Olton et al, 1978; Risold and Swanson, 1997; Wirtshafter and Wilson, 2019; Zhou et al, 1999)
While the percentage of place cells is lower in the LS than in CA1, the observed LS place cells are similar to those in the CA1 in terms of field numbers and field size
We suggest that these characteristics are the result of selective LS innervation by HPC place cells, which allows reward related information to be sent to areas downstream of the LS
Summary
The lateral septum (LS), which is innervated by all CA fields of the hippocampus, contains place cells, and processes spatial information received from the hippocampus (Bezzi, 2005; Olton et al, 1978; Risold and Swanson, 1997; Wirtshafter and Wilson, 2019; Zhou et al, 1999). Specific firing has been well documented and characterized in other brain areas, including in the entorhinal cortex (Fyhn et al, 2004; Hafting et al, 2005; Quirk et al, 1992), where this firing is believed to play a role in path integration (Fyhn et al, 2007; Knierim et al, 2014; Monaco et al, 2011; Moser et al, 2008), and in the lateral septum
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