Dietary Vegetable Powders Modulate Immune Homeostasis and Intestinal Microbiota in Mice.

Yixin Zou,Haifei Yu,Zheng Ruan,Li Zhang

doi:10.3390/foods11010027

Abstract

As the largest immune organ of the human body, the intestine also plays a vital role in nutrient digestion and absorption. Some vegetables are considered to have improvement effects on the intestine. This experiment explored the effects of freeze-dried asparagus, broccoli and cabbage powder on the intestinal immune homeostasis and microflora of mice. Thirty-two mice were divided into four groups (n = 8), including control group (fed normal diet), asparagus group (fed normal diet with 5% asparagus power), broccoli group (fed normal diet with 5% broccoli power) and cabbage group (fed normal diet with 5% cabbage power). The experiment lasted 21 days. The results showed that the serum immunoglobulin concentration (IgA and IgM) and intestinal cytokine content (like IFN-γ and TNF-α) were increased after vegetable powder supplement. The experiment also detected that vegetable powder supplementation changed intestinal flora and their metabolites (short-chain fatty acid), which showed that the abundance of Lachnospiraceae and Bacteroides were decreased, while the abundance of Firmicutes and Lactobacillus as well as propionic acid and butyric acid contents were increased. Together, these vegetable powders, especially cabbage, changed the intestinal immune response and microbial activity of mice.

Highlights

The intestine is the body’s largest immune organ, as well as an important place for digestion and absorption of nutrients
There is a special group of organisms that plays a very key role in the intestinal tract called “the intestinal flora”, which contains about
These microorganisms form a symbiotic system with the intestinal tract and participate in a series of physiological processes such as digestion and immunity

Summary

Introduction

The intestine is the body’s largest immune organ, as well as an important place for digestion and absorption of nutrients. In recent investigations of human cancers, colorectal cancer is increasing year by year in global incidence and has occupied the third position [1]. For this reason, maintaining a healthy gut is important. Other bacteria can delay the development of CRC by regulating immune response, improving intestinal barrier function and inhibiting cell proliferation. A diet can improve the development of intestinal diseases through the intestinal flora example, a high-fiber diet can increase the abundance of Firmicutes in the intestinal reduce the abundance of Bacteroidetes and increase the concentration of short-chain acids, which can promote the effect of immunotherapy; nulin and fructose-oligosac rides added to the human diet can stimulate the proliferation of bifidobacteria [6

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Discussion

Conclusion