Dietary Total Antioxidant Capacity Is Inversely Associated with Prediabetes and Insulin Resistance in Bialystok PLUS Population.

Monika Cyuńczyk,Marcin Kondraciuk,Kinga Zujko,Małgorzata Elżbieta Zujko,Magdalena Zalewska,Karol Adam Kamiński,Anna Maria Witkowska,Magda Łapińska,Jacek Jamiołkowski

doi:10.3390/antiox11020283

Monika Cyuńczyk, Marcin Kondraciuk + Show 7 more

Open Access

https://doi.org/10.3390/antiox11020283

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Abstract

The aim of this study was to assess the relationship between the dietary total antioxidant capacity (DTAC) and occurrence of prediabetes, diabetes and insulin resistance in the Bialystok PLUS (Polish Longitudinal University Study) population. Daily food consumption was estimated by 3-days 24-h dietary recalls. DTAC was calculated using the date of food consumption and antioxidant potential of foods measured by FRAP (ferric ion reducing antioxidant potential) method. The following measurements were performed to identify prediabetes, diabetes and HOMA-IR: fasting glucose (FG), 2h postprandial glucose level (2h-PG), fasting insulin (FI), glycated hemoglobin HbA1c. Logistic regression models were used to assess the relationship between DTAC and prediabetes and diabetes. This study demonstrated that higher quartile of DTAC, after adjustment for confounding variables, was significantly associated with a reduced odds ratio for the prevalence of prediabetes in Bialystok PLUS population aged 35–65 years. DTAC was also significantly inversely associated with HOMA-IR in multivariate linear regression model. DTAC was positively related to individual dietary antioxidants (polyphenols, antioxidant vitamins and minerals). Reduced DTAC may be considered as an additional risk factor for the development of diabetes. Therefore, dietary recommendations for prevention and therapy of diabetes should take into account the high DTAC.

Highlights

Results are presented as odds ratios (ORs) and confidence intervals (CIs); *—p < 0.05; 1 —analysis adjusted for age, sex and daily energy intake, 2 —analysis adjusted for age, sex, family history of diabetes, educational level, smoking status, physical activity, dyslipidemia, hypertension, Body mass index (BMI), waist circumference, alcohol consumption, daily energy intake; FG—fasting glucose, 2h-G—2-h plasma glucose during oral glucose tolerance test, HbA1c—
In model 3 dietary total antioxidant capacity (DTAC) was inversely associated with HOMA-IR (β = −0.39, CI = −0.75–−0.14, p = 0.024, R2 = 0.07)
This study demonstrated that higher quartile of DTAC, after adjustment for confounding variables, was significantly associated with a reduced odds ratio for the prevalence of prediabetes in the Bialystok PLUS population aged 35–65 years

Summary

Introduction

The aim of this study was to assess the relationship between the dietary total antioxidant capacity (DTAC) and occurrence of prediabetes, diabetes and insulin resistance in the Bialystok. DTAC was calculated using the date of food consumption and antioxidant potential of foods measured by FRAP (ferric ion reducing antioxidant potential) method. The following measurements were performed to identify prediabetes, diabetes and HOMA-IR: fasting glucose (FG), 2h postprandial glucose level (2h-PG), fasting insulin (FI), glycated hemoglobin HbA1c. Logistic regression models were used to assess the relationship between DTAC and prediabetes and diabetes. This study demonstrated that higher quartile of DTAC, after adjustment for confounding variables, was significantly associated with a reduced odds ratio for the prevalence of prediabetes in Bialystok PLUS population aged 35–65 years.

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