Dietary supplementation of Bacillus subtilis, Saccharomyces cerevisiae and their symbiotic effect on serum biochemical parameters in broilers challenged with Clostridium perfringens

Hani H Al-Baadani,Alaeldein M Abudabos,Saud I Al-Mufarrej,Ali A Al-Baadani,Ibrahim A Alhidary

doi:10.1080/09712119.2018.1454325

Hani H Al-Baadani, Alaeldein M Abudabos + Show 3 more

Open Access

https://doi.org/10.1080/09712119.2018.1454325

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Abstract

ABSTRACTThe study was conducted to evaluate the effect of an antimicrobial growth promoter (AGP), probiotic, prebiotic and their combination (symbiotic effect) on blood biochemistry of broiler chickens challenged with Clostridium perfringens. Two hundred and forty, 1-d-old Ross 308 broilers were distributed into six groups – the negative control (basal diet), positive control (C. perfringens infection), AGP + challenge, probiotic + challenge, prebiotic + challenge and synbiotic + challenge. The results showed significant differences in total protein, albumin, globulin and glucose in AGP with no significant difference between negative and positive control. Triglyceride and total cholesterol decreased significantly among all groups compared with positive control. Heterophils and heterophils-to-lymphocytes ratio (H/L) were significantly (P < .001) lower, and lymphocytes were significantly (P < .001) higher in all groups compared with positive control. It can be concluded from this study that the synergistic effect of Bacillus subtilis and Technomos was superior to that of the AGP in improving the blood biochemical profile of broiler challenged with C. perfringens.

Highlights

Necrotic enteritis is one of the deadliest diseases in broilers caused by Clostridium perfringens, which damages the intestinal mucosa, decreases digestion and absorption of nutrients (Abudabos et al, 2018) and leads to loss of performance (Abudabos and Yehia, 2013)
At the subtherapeutic level, antibiotics are used as antimicrobial growth promoters (AGPs) in poultry feed, which improve growth and prevent some specific intestinal diseases (Alzawqari et al, 2016; Abudabos et al, 2016, 2017; Khan et al, 2016)
The objective of the present study was to compare the effects of AGP, probiotic, prebiotic and their combination on blood biochemistry and leukocytes dynamics in broiler chickens challenged with C. perfringens during the finisher stages

Summary

Introduction

Necrotic enteritis is one of the deadliest diseases in broilers caused by Clostridium perfringens, which damages the intestinal mucosa, decreases digestion and absorption of nutrients (Abudabos et al, 2018) and leads to loss of performance (Abudabos and Yehia, 2013). Antibiotics are used several times at higher doses than a subtherapeutic level in animals to cure the infectious diseases (Khan, Nikosefat, et al, 2012; Khan, Naz, Nikousefat, et al, 2012). At the subtherapeutic level, antibiotics are used as antimicrobial growth promoters (AGPs) in poultry feed, which improve growth and prevent some specific intestinal diseases (Alzawqari et al, 2016; Abudabos et al, 2016, 2017; Khan et al, 2016). An intensive research is going to look for alternatives to AGPs to improve the performance in poultry (Khan, Naz, Tufarelli, et al, 2012; Khan, Naz, Javadani, et al, 2012). Probiotics and prebiotics are being extensively used in poultry production (Chand et al, 2016)

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