Abstract
Lifelong dietary restriction beginning at 3 to 6 weeks of age in rodents is known to decelerate the rate of aging, increase mean and maximum life-spans, and inhibit the occurrence of many spontaneous cancers. Little is known about the effects of dietary restriction started in middle age. In the experiments now reported, the food intake of 12- to 13-month-old mice of two long-lived strains was restricted by using nutrient-enriched diets in accordance with the concept of “undernutrition without malnutrition.” The mice on the restricted diet averaged 10 to 20% increases in mean and maximum survival times as compared with the control mice. Spontaneous lymphoma was inhibited by the food restriction. Reproduced with permission from Science . Copyright 1982 American Association for the Advancement of Science. Richard Weindruch, Roy L. Walford, Dietary Restriction in Mice Beginning at One Year of Age: Effect on Life-Span and Spontaneous Cancer Incidence. Science 215 , 1415-1418 (1982).
Published Version
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