Abstract
This study was conducted to determine whether the feeding of dietary L-carnitine (CN) improves the intestinal absorption of fat and α-tocopherol (αTOH) in ovariectomized (OX) rats. OX adult rats were weight-matched and assigned to 2 groups fed a modified AIN-93G diet containing αTOH-stripped soybean oil without (−CN) or with (+CN) supplemental CN at 150 mg/kg diet. At 5 wk, each rat with a lymph cannula was infused intraduodenally at 3.0 mL/h with a lipid emulsion consisting of 565 μmol triolein labeled with 14C (14C-OA), 3.6 μmol αTOH, and 396 μmol sodium taurocholate in 24 mL PBS buffer. Lymph was collected hourly for 8 h and analyzed for lipids. The lymphatic absorption of αTOH for 8 h in +CN rats (899 ± 201 nmol) was higher (P < 0.05) than in −CN rats (587 ± 92 nmol). The absorption of 14C-OA in +CN rats (53.5 ± 4.0% dose/8 h) also was increased (P < 0.05) compared with −CN rats (47.6 ± 5.0% dose/8 h). Lymph flow did not differ between the groups. When bile was diverted but with infusion of sodium taurocholate, the lymphatic absorption of lipids did not differ. The present study provides evidence that dietary CN enhances the rates and amounts of lymphatic absorption of αTOH and fat in OX rats. Our findings suggest that dietary CN may influence the process of lipid packaging and absorption by the enterocyte in OX rats, and may explain in part the increased status of αTOH in CN-fed animals.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
