Abstract
In reply We thank Dr Friedman for his interest in our article 1 and for his comments regarding a model of the pathogenesis of age-related macular degeneration. 2 We agree that there is little evidence to suggest that fatty plaques, characteristic of atherosclerosis in large vessels, accumulate in choroidal vessels. However, some studies have shown that risk factors for atherosclerosis are related to the presence of age-related macular degeneration. In a study of Dutch elderly, the risk for age-related macular degeneration was higher among people with plaques in the carotid artery and at the carotid bifurcation and in those with lower-extremity arterial disease. 3 The presence of shared risk factors for arterial disease in several locations is consistent with the possibility that some processes in the pathogenesis of small-vessel arteriosclerosis, atherosclerosis, and age-related maculopathy may be shared. Experimental investigations are required to predict the pathogenic interrelationships of these conditions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
