Abstract
The interaction of dietary and genetic factors may affect the development of bone deterioration. This study investigated whether the effects of dietary acid load (DAL) on bone loss in postmenopausal Chinese women were moderated by the insulin-like growth factor-1 (IGF-1) single nucleotide polymorphism, a known gene that plays a role in the regulation of bone formation and bone remodeling. A total of 217 healthy participants were recruited from the National Council of Senior Citizens Organizations Malaysia. Serum collagen type 1 cross-linked C-telopeptide was used as a surrogate bone marker to assess bone resorption and Agena® MassARRAY genotyping analysis was used to identify the signaling of IGF-1 rs35767. The dietary acid load was measured by potential renal acid load score while physical activity was ascertained using the Global Physical Activity Questionnaire. Hierarchical regression was applied to test the main and interaction effects of DAL and IGF-1 genotypes in bone resorption. The result supported the diet-dependent acid-base balance theory that higher DAL was positively associated with bone resorption (β = 0.152, p = 0.031, F(6,207) = 2.11, sig-F = 0.036, R2 = 0.079). However, the results indicated that there was no significant correlation between IGF-1 and bone resorption, or any significant interaction between DAL and IGF-1. In conclusion, there was no moderating effect of IGF-1 on the relationship between DAL and bone resorption.
Highlights
Osteoporosis is a skeletal disorder characterized by a low bone mass and bone microarchitectural deterioration which represents a major worldwide healthcare problem that affects more than 200 million people [1]
The aim of this study was to examine whether the effects of an alkaline diet on bone resorption among Malaysian Chinese postmenopausal women were moderated by insulin-like growth factor-1 (IGF-1) genetic polymorphism
A long recognized public health problem among populations residing in subtropical countries [41,42], vitamin D deficiency has emerged as a significant public health issue in tropical countries with almost all year round UV-B radiation being a sufficient wavelength necessary for cutaneous synthesis of vitamin D [43,44,45,46,47], including Malaysia [48,49,50,51]
Summary
Osteoporosis is a skeletal disorder characterized by a low bone mass and bone microarchitectural deterioration which represents a major worldwide healthcare problem that affects more than 200 million people [1]. Hip fractures are the most serious outcome of osteoporosis while vertebral fractures are more common and have a substantial impact on mortality and morbidity [2]. The causes of osteoporosis and bone fractures are multifactorial and include lower vitamin D, aging, being women, low calcium intake, physical inactivity, and estrogen deficiency [3,4]. During the post-menopausal period, the sharp decline in production of estrogen may reduce the rate of bone formation and increase bone turnover [5]. Based on the aging trend of world’s
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