Abstract

If the endogenous acid-base balance is not well regulated, dietary acid load contributes to metabolic acidosis, leading to inflammation and cell transformation, which can contribute to the development of cancer. Nevertheless, there is still limited epidemiologic evidence on the association between diet-dependent acid load and cancer risk, particularly for breast cancer (BC), although an increased risk of recurrence among BC survivors was reported for a high acid load. Therefore, we have explored in the present study its role in BC risk.

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