Abstract
Objective: Acidic and basic reaction products are developed by d-c iontophoresis. These ions result from the process of electrolysis between first and second order conductors, and move to the surface of skin. Especially the OH- ions must not contact the skin, otherwise cauterization would be the result. By the use of sponges cauterization can be delayed. Iontophoresis must be finished just before this reaction starts and is therefore limited in time. The uptake of drugs by iontophoresis in this time is too short; tissue levels during 20 minutes application are usually too low. During permanent iontophoresis the tissue levels increase proportional in time (absorption phase).
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